The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring
We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-6 |
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| creator | Wang, Lingxing Li, Meimei Huang, Ziyang Wang, Zhenhua |
| description | We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P |
| doi_str_mv | 10.1155/2014/419805 |
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Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P<0.05). Maternal hypoxia from day 15 to 21 of pregnancy had no effect on adult collagen levels. Our results indicate that maternal hypoxia at critical windows of cardiovascular development can induce pathological cardiac remodeling in the adult rat offspring.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/419805</identifier><identifier>PMID: 25013780</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Age ; Animals ; Biotechnology industry ; Blood pressure ; Cardiomyocytes ; Cardiovascular disease ; Collagen ; Collagen - biosynthesis ; Extracellular matrix ; Extracellular Matrix - metabolism ; Female ; Heart - growth & development ; Heart Ventricles - metabolism ; Humans ; Hypertension ; Hypoxia ; Hypoxia - metabolism ; Hypoxia - pathology ; Myocardium - metabolism ; Pathology ; Physiological aspects ; Pregnancy ; Proteins ; Rats ; Rodents ; Studies</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-6</ispartof><rights>Copyright © 2014 Lingxing Wang et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Lingxing Wang et al. Lingxing Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Lingxing Wang et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-70ca7090004cc76ea9702d1940f6d94fdf6ca5b0c5c996efba8b5d77226057153</citedby><cites>FETCH-LOGICAL-c527t-70ca7090004cc76ea9702d1940f6d94fdf6ca5b0c5c996efba8b5d77226057153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071786/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071786/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25013780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sobrevia, Luis</contributor><creatorcontrib>Wang, Lingxing</creatorcontrib><creatorcontrib>Li, Meimei</creatorcontrib><creatorcontrib>Huang, Ziyang</creatorcontrib><creatorcontrib>Wang, Zhenhua</creatorcontrib><title>The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P<0.05). Maternal hypoxia from day 15 to 21 of pregnancy had no effect on adult collagen levels. Our results indicate that maternal hypoxia at critical windows of cardiovascular development can induce pathological cardiac remodeling in the adult rat offspring.</description><subject>Age</subject><subject>Animals</subject><subject>Biotechnology industry</subject><subject>Blood pressure</subject><subject>Cardiomyocytes</subject><subject>Cardiovascular disease</subject><subject>Collagen</subject><subject>Collagen - biosynthesis</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - metabolism</subject><subject>Female</subject><subject>Heart - growth & development</subject><subject>Heart Ventricles - metabolism</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypoxia</subject><subject>Hypoxia - metabolism</subject><subject>Hypoxia - pathology</subject><subject>Myocardium - metabolism</subject><subject>Pathology</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rodents</subject><subject>Studies</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkt1rHCEUxYfS0IQkT31uEfpSUrZRx4_xJbBs2iYQSKHps7iOzhpmdaszTfa_710m3X68xBfF--N47vVU1WuCPxLC-TnFhJ0zohrMX1RHtCZsJggjL_fnuj6sTku5x7AaIrASr6pDyjGpZYOPqny3cug6-n500TqUPLrabtJjMKgdc4gdugzeu-zigL5m10UT7RZ9G0znCkoRLUxug7Fokfoe7iKaWzuux94MAaohogHk5-3YD-jW-7LZSZ5UB970xZ0-7cfV98-f7hZXs5vbL9eL-c3MciqHmcTWSKzANrNWCmeUxLQlimEvWsV864U1fIktt0oJ55emWfJWSkoF5pLw-ri6mHQ343LtWgs9ZNNr8LA2eauTCfrfSgwr3aWfmmFJZCNA4P2TQE4_RlcGvQ7FOug0ujQWTQQhooa38PMoZ0zCN9U1oO_-Q-_TmCNMAihOmZCKij9UZ3qnQ_QJLNqdqJ4zCpOgSjGgPkyUzamU7Py-O4L1Lh96lw895QPot38PZM_-TgMAZxOwCrE1D-EZtTcT7ABx3uxhJrGUov4FIfvKGg</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Wang, Lingxing</creator><creator>Li, Meimei</creator><creator>Huang, Ziyang</creator><creator>Wang, Zhenhua</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AFFIF</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring</title><author>Wang, Lingxing ; Li, Meimei ; Huang, Ziyang ; Wang, Zhenhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-70ca7090004cc76ea9702d1940f6d94fdf6ca5b0c5c996efba8b5d77226057153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age</topic><topic>Animals</topic><topic>Biotechnology industry</topic><topic>Blood pressure</topic><topic>Cardiomyocytes</topic><topic>Cardiovascular disease</topic><topic>Collagen</topic><topic>Collagen - biosynthesis</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - metabolism</topic><topic>Female</topic><topic>Heart - growth & development</topic><topic>Heart Ventricles - metabolism</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypoxia</topic><topic>Hypoxia - metabolism</topic><topic>Hypoxia - pathology</topic><topic>Myocardium - metabolism</topic><topic>Pathology</topic><topic>Physiological aspects</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rodents</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lingxing</creatorcontrib><creatorcontrib>Li, Meimei</creatorcontrib><creatorcontrib>Huang, Ziyang</creatorcontrib><creatorcontrib>Wang, Zhenhua</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>قاعدة دراسات المرأة - e-Marefa Women Studies</collection><collection>معرفة - 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Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P<0.05). Maternal hypoxia from day 15 to 21 of pregnancy had no effect on adult collagen levels. Our results indicate that maternal hypoxia at critical windows of cardiovascular development can induce pathological cardiac remodeling in the adult rat offspring.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25013780</pmid><doi>10.1155/2014/419805</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Animals Biotechnology industry Blood pressure Cardiomyocytes Cardiovascular disease Collagen Collagen - biosynthesis Extracellular matrix Extracellular Matrix - metabolism Female Heart - growth & development Heart Ventricles - metabolism Humans Hypertension Hypoxia Hypoxia - metabolism Hypoxia - pathology Myocardium - metabolism Pathology Physiological aspects Pregnancy Proteins Rats Rodents Studies |
| title | The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring |
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