The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring

We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-6
Hauptverfasser:	Wang, Lingxing, Li, Meimei, Huang, Ziyang, Wang, Zhenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Biotechnology industry Blood pressure Cardiomyocytes Cardiovascular disease Collagen Collagen - biosynthesis Extracellular matrix Extracellular Matrix - metabolism Female Heart - growth & development Heart Ventricles - metabolism Humans Hypertension Hypoxia Hypoxia - metabolism Hypoxia - pathology Myocardium - metabolism Pathology Physiological aspects Pregnancy Proteins Rats Rodents Studies
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Zusammenfassung:	We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2014/419805