Regulatory constraints in the generation and differentiation of IgE-expressing B cells

Regulatory constraints in the generation and differentiation of IgE-expressing B cells

Highlights • IgE reporter mice enable specific detection of IgE+ B cells in vivo. • IgE+ B cells appear transiently in germinal centers. • IgE+ plasma cells develop in both extrafollicular foci and germinal centers. • IgE+ B cells are predisposed to a short-lived plasma cell fate. • The existence an...

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Veröffentlicht in:Current opinion in immunology 2014-06, Vol.28, p.64-70
Hauptverfasser: Yang, Zhiyong, Robinson, Marcus J, Allen, Christopher D C
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Cell Differentiation
Cell Lineage
Germinal Center - immunology
Humans
Immunoglobulin Class Switching
Immunoglobulin E - immunology
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Zusammenfassung:Highlights • IgE reporter mice enable specific detection of IgE+ B cells in vivo. • IgE+ B cells appear transiently in germinal centers. • IgE+ plasma cells develop in both extrafollicular foci and germinal centers. • IgE+ B cells are predisposed to a short-lived plasma cell fate. • The existence and importance of IgE+ memory B cells remain controversial.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2014.02.001