Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism
Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipi...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2014-07, Vol.58 (7), p.4227-4229 |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | DEL POZO, J. L FERNANDEZ-ROS, N SAEZ, E HERRERO, J. I YUSTE, J. R BANALES, J. M |
| description | Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism. |
| doi_str_mv | 10.1128/AAC.02856-14 |
| format | Article |
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L ; FERNANDEZ-ROS, N ; SAEZ, E ; HERRERO, J. I ; YUSTE, J. R ; BANALES, J. M</creator><creatorcontrib>DEL POZO, J. L ; FERNANDEZ-ROS, N ; SAEZ, E ; HERRERO, J. I ; YUSTE, J. R ; BANALES, J. M</creatorcontrib><description>Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.02856-14</identifier><identifier>PMID: 24798272</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Acetamides ; Acetamides - adverse effects ; Acetamides - therapeutic use ; Acidosis, Lactic ; Acidosis, Lactic - chemically induced ; Acidosis, Lactic - therapy ; Adult ; Aged ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Clinical Therapeutics ; DNA, Mitochondrial ; DNA, Mitochondrial - genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Linezolid ; Liver Transplantation ; Male ; Medical sciences ; Mitochondria ; Mitochondria - genetics ; Nocardia asteroides - drug effects ; Nocardia Infections - drug therapy ; Oxazolidinones ; Oxazolidinones - adverse effects ; Oxazolidinones - therapeutic use ; Pharmacology. Drug treatments ; Polymorphism, Single Nucleotide ; RNA, Ribosomal, 16S - genetics ; Tuberculosis, Pulmonary - drug therapy</subject><ispartof>Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4227-4229</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2014, American Society for Microbiology. All Rights Reserved. 2014 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a481t-d51304f8bed322c1dc93a1135e87d9a8cc4609d7ae9c449e057f2a08ef06064e3</citedby><cites>FETCH-LOGICAL-a481t-d51304f8bed322c1dc93a1135e87d9a8cc4609d7ae9c449e057f2a08ef06064e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068560/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068560/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28577294$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24798272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DEL POZO, J. L</creatorcontrib><creatorcontrib>FERNANDEZ-ROS, N</creatorcontrib><creatorcontrib>SAEZ, E</creatorcontrib><creatorcontrib>HERRERO, J. I</creatorcontrib><creatorcontrib>YUSTE, J. R</creatorcontrib><creatorcontrib>BANALES, J. M</creatorcontrib><title>Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.</description><subject>Acetamides</subject><subject>Acetamides - adverse effects</subject><subject>Acetamides - therapeutic use</subject><subject>Acidosis, Lactic</subject><subject>Acidosis, Lactic - chemically induced</subject><subject>Acidosis, Lactic - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Clinical Therapeutics</subject><subject>DNA, Mitochondrial</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Linezolid</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mitochondria</subject><subject>Mitochondria - genetics</subject><subject>Nocardia asteroides - drug effects</subject><subject>Nocardia Infections - drug therapy</subject><subject>Oxazolidinones</subject><subject>Oxazolidinones - adverse effects</subject><subject>Oxazolidinones - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymorphism, Single Nucleotide</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1vFCEYh4mxsWv15tlwMdGkU4Fh-Lg0maxam4zaw3omFBiHZmbYAtOm_vXS7lr14Im84cnv_XgAeIXRCcZEvG_b9QkiomEVpk_ACiMpKtZI9hSsEGKsogLRQ_A8pStU6kaiZ-CQUC4F4WQFrjs_u59h9LY6n-1inIWdNtkb2BpvQ_IJ-hlubgPs_I2LcBP1nLajnjO80Nm7OSd46_MA8-DgF5-DGcJso9cj_PC1hS3hiJ3BizDeTSFuB5-mF-Cg12NyL_fvEfj-6eNm_bnqvp2dr9uu0lTgXNkG14j24tLZmhCDrZG1xrhunOBWamEMZUharp00lEqHGt4TjYTrEUOMuvoInO5yt8vl5Kwpo0Y9qm30k453Kmiv_v2Z_aB-hBtFESvXRCXg7T4ghuvFpawmn4wby_IuLEnhhnLBGK1FQY93qIkhpej6xzYYqXtLqlhSD5YUpgV_t8N1moi6CkucyyX-x77-e43H4N8KC_BmD-hk9NgXQcanP5xoOCeS1r8A5Nanbg</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>DEL POZO, J. L</creator><creator>FERNANDEZ-ROS, N</creator><creator>SAEZ, E</creator><creator>HERRERO, J. I</creator><creator>YUSTE, J. R</creator><creator>BANALES, J. M</creator><general>American Society for Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20140701</creationdate><title>Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism</title><author>DEL POZO, J. L ; FERNANDEZ-ROS, N ; SAEZ, E ; HERRERO, J. I ; YUSTE, J. R ; BANALES, J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a481t-d51304f8bed322c1dc93a1135e87d9a8cc4609d7ae9c449e057f2a08ef06064e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetamides</topic><topic>Acetamides - adverse effects</topic><topic>Acetamides - therapeutic use</topic><topic>Acidosis, Lactic</topic><topic>Acidosis, Lactic - chemically induced</topic><topic>Acidosis, Lactic - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Clinical Therapeutics</topic><topic>DNA, Mitochondrial</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Linezolid</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mitochondria</topic><topic>Mitochondria - genetics</topic><topic>Nocardia asteroides - drug effects</topic><topic>Nocardia Infections - drug therapy</topic><topic>Oxazolidinones</topic><topic>Oxazolidinones - adverse effects</topic><topic>Oxazolidinones - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymorphism, Single Nucleotide</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEL POZO, J. 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I</au><au>YUSTE, J. R</au><au>BANALES, J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>58</volume><issue>7</issue><spage>4227</spage><epage>4229</epage><pages>4227-4229</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><coden>AACHAX</coden><abstract>Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>24798272</pmid><doi>10.1128/AAC.02856-14</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4227-4229 |
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| source | MEDLINE; PubMed Central; EZB Electronic Journals Library |
| subjects | Acetamides Acetamides - adverse effects Acetamides - therapeutic use Acidosis, Lactic Acidosis, Lactic - chemically induced Acidosis, Lactic - therapy Adult Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Clinical Therapeutics DNA, Mitochondrial DNA, Mitochondrial - genetics Female Genetic Predisposition to Disease Humans Linezolid Liver Transplantation Male Medical sciences Mitochondria Mitochondria - genetics Nocardia asteroides - drug effects Nocardia Infections - drug therapy Oxazolidinones Oxazolidinones - adverse effects Oxazolidinones - therapeutic use Pharmacology. Drug treatments Polymorphism, Single Nucleotide RNA, Ribosomal, 16S - genetics Tuberculosis, Pulmonary - drug therapy |
| title | Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism |
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