Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism

Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-07, Vol.58 (7), p.4227-4229
Hauptverfasser:	DEL POZO, J. L, FERNANDEZ-ROS, N, SAEZ, E, HERRERO, J. I, YUSTE, J. R, BANALES, J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides Acetamides - adverse effects Acetamides - therapeutic use Acidosis, Lactic Acidosis, Lactic - chemically induced Acidosis, Lactic - therapy Adult Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Clinical Therapeutics DNA, Mitochondrial DNA, Mitochondrial - genetics Female Genetic Predisposition to Disease Humans Linezolid Liver Transplantation Male Medical sciences Mitochondria Mitochondria - genetics Nocardia asteroides - drug effects Nocardia Infections - drug therapy Oxazolidinones Oxazolidinones - adverse effects Oxazolidinones - therapeutic use Pharmacology. Drug treatments Polymorphism, Single Nucleotide RNA, Ribosomal, 16S - genetics Tuberculosis, Pulmonary - drug therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.02856-14