β-Adrenoceptors and synaptic plasticity in the perirhinal cortex

Highlights • Bath application of isoprenaline induces LTP in the perirhinal cortex. • LTP at amygdala to perirhinal synapses requires β1- but not β2-ADRs. • Combination of β1-ADRs, NMDARs, and VGCC required for LTP.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2014-07, Vol.273 (100), p.163-173
Hauptverfasser:	Laing, M, Bashir, Z.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology amygdala Amygdala - drug effects Amygdala - physiology Animals Biological and medical sciences Calcium Channels - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Electric Stimulation Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Isoproterenol - pharmacology Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Microelectrodes Neural Pathways - drug effects Neural Pathways - physiology Neurology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology noradrenaline perirhinal cortex Rats Receptors, Adrenergic, beta-1 - metabolism Receptors, Adrenergic, beta-2 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Temporal Lobe - drug effects Temporal Lobe - physiology Tissue Culture Techniques Vertebrates: nervous system and sense organs visual recognition β-adrenoceptors
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Beschreibung
Zusammenfassung:	Highlights • Bath application of isoprenaline induces LTP in the perirhinal cortex. • LTP at amygdala to perirhinal synapses requires β1- but not β2-ADRs. • Combination of β1-ADRs, NMDARs, and VGCC required for LTP.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.04.070