Separating analgesia from reward within the ventral tegmental area

Highlights • Cholinergic activation of the ventral tegmental area (VTA) generates analgesia and reward. • Analgesia and reward can be neuropharmacologically separated within the posterior VTA (pVTA). • Nicotinic receptor antagonism within pVTA fails to attenuate analgesia, but prevents reward. • A n...

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Veröffentlicht in:	Neuroscience 2014-03, Vol.263, p.72-87
Hauptverfasser:	Schifirneţ, E, Bowen, S.E, Borszcz, G.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Animals Atropine - pharmacology Biological and medical sciences Carbachol - pharmacology Cholinergic Agonists - pharmacology Fundamental and applied biological sciences. Psychology Male Mecamylamine - pharmacology Muscarinic Antagonists - pharmacology Neurology Nicotinic Antagonists - pharmacology Pain Threshold - drug effects Rats Rats, Long-Evans Reward Ventral Tegmental Area - drug effects Ventral Tegmental Area - metabolism Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Cholinergic activation of the ventral tegmental area (VTA) generates analgesia and reward. • Analgesia and reward can be neuropharmacologically separated within the posterior VTA (pVTA). • Nicotinic receptor antagonism within pVTA fails to attenuate analgesia, but prevents reward. • A new subdivision of the VTA (midVTA) was identified. • Cholinergic activation of the midVTA failed to support either analgesia or reward.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.01.009