Postnatal development of eupneic ventilation and metabolism in rats chronically exposed to moderate hyperoxia

Highlights • Newborn rats reared in hyperoxia hypoventilate shortly after return to normoxia. • Smaller hyperoxic ventilatory responses suggest reduced carotid body contribution. • Respiratory burst frequency is also slower in brainstem-spinal cord preparations. • The decreased minute ventilation ca...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2014-07, Vol.198, p.1-12
Hauptverfasser:	Bavis, Ryan W, van Heerden, Eliza S, Brackett, Diane G, Harmeling, Luke H, Johnson, Stephen M, Blegen, Halward J, Logan, Sarah, Nguyen, Giang N, Fallon, Sarah C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological Clocks - physiology Blood Chemical Analysis Body Temperature - physiology Brain Stem - growth & development Brain Stem - physiopathology Brainstem-spinal cord preparation Carbon Dioxide - metabolism Chemoreceptor Cells - physiology Control of breathing Developmental plasticity Heart - growth & development Heart Rate - physiology Hyperoxia - physiopathology Hypometabolism Medical Education Oxygen - metabolism Oxygen Consumption - physiology Perinatal hyperoxia Phosphorylation - physiology Pulmonary Ventilation - physiology Pulmonary/Respiratory Rats, Sprague-Dawley Respiratory Mechanics - physiology Spinal Cord - growth & development Spinal Cord - physiopathology Tissue Culture Techniques
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Zusammenfassung:	Highlights • Newborn rats reared in hyperoxia hypoventilate shortly after return to normoxia. • Smaller hyperoxic ventilatory responses suggest reduced carotid body contribution. • Respiratory burst frequency is also slower in brainstem-spinal cord preparations. • The decreased minute ventilation cannot be explained by decreased metabolic rate. • Diminished metabolic rates appear to be regulated, akin to hypoxic hypometabolism.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2014.03.010