Maternal-Fetal Immune Tolerance, Block by Block

Maternal-Fetal Immune Tolerance, Block by Block

How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role fo...

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Veröffentlicht in:Cell 2012-07, Vol.150 (1), p.7-9
Hauptverfasser: Gobert, Michael, Lafaille, Juan J.
Format: Artikel
Sprache:eng
Schlagworte:
antigens
eggs
evolution
immunosuppression (physiological)
mammals
T-lymphocytes
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Zusammenfassung:How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.06.020