KASHing up with the nucleus: novel functional roles of KASH proteins at the cytoplasmic surface of the nucleus

KASHing up with the nucleus: novel functional roles of KASH proteins at the cytoplasmic surface of the nucleus

Highlights • KASH proteins localize to the cytoplasmic surface of the nucleus. • New functions for KASH proteins interacting with the cytoskeleton are discussed. • KASH proteins play a central role in cellular mechanics. • Genetics mutations in KASH proteins are associated with a variety of human di...

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Veröffentlicht in:Current opinion in cell biology 2014-06, Vol.28, p.69-75
Hauptverfasser: Luxton, GW Gant, Starr, Daniel A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Nucleus - genetics
Cell Nucleus - metabolism
Cytoplasm - metabolism
Humans
Internal Medicine
Kinesin - metabolism
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Protein Binding
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Zusammenfassung:Highlights • KASH proteins localize to the cytoplasmic surface of the nucleus. • New functions for KASH proteins interacting with the cytoskeleton are discussed. • KASH proteins play a central role in cellular mechanics. • Genetics mutations in KASH proteins are associated with a variety of human diseases.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2014.03.002