Wild-Type RAS: Keeping Mutant RAS in CHK

Mutant RAS-driven tumorigenesis was thought for decades to arise independently of wild-type RAS isoforms, but recent evidence indicates wild-type isoforms are involved. In this issue of Cancer Cell, Grabocka and colleagues report how the loss of wild-type RAS alters oncogenic signaling and dampens t...

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Veröffentlicht in:	Cancer cell 2014-02, Vol.25 (2), p.137-138
Hauptverfasser:	Anastassiadis, Theonie, Brown, Eric J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Transformation, Neoplastic - pathology DNA Damage - genetics Female GTP Phosphohydrolases - metabolism Humans Membrane Proteins - metabolism Neoplasms - pathology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) - metabolism ras Proteins - genetics
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Beschreibung
Zusammenfassung:	Mutant RAS-driven tumorigenesis was thought for decades to arise independently of wild-type RAS isoforms, but recent evidence indicates wild-type isoforms are involved. In this issue of Cancer Cell, Grabocka and colleagues report how the loss of wild-type RAS alters oncogenic signaling and dampens the DNA-damage response, thereby affecting tumor progression and chemosensitivity.
ISSN:	1535-6108 1878-3686
DOI:	10.1016/j.ccr.2014.01.029