Oral retinyl palmitate or retinoic acid corrects mucosal IgA responses toward an intranasal influenza virus vaccine in vitamin A deficient mice
Highlights • The mucosal IgA response to the influenza virus FluMist vaccine is impaired in vitamin A deficient animals. • Retinyl palmitate corrects impaired mucosal IgA responses toward the FluMist vaccine in vitamin A deficient animals. • Retinoic acid corrects impaired mucosal IgA responses towa...
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| Veröffentlicht in: | Vaccine 2014-05, Vol.32 (22), p.2521-2524 |
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| container_issue | 22 |
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| container_title | Vaccine |
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| creator | Surman, S.L Jones, B.G Sealy, R.E Rudraraju, R Hurwitz, J.L |
| description | Highlights • The mucosal IgA response to the influenza virus FluMist vaccine is impaired in vitamin A deficient animals. • Retinyl palmitate corrects impaired mucosal IgA responses toward the FluMist vaccine in vitamin A deficient animals. • Retinoic acid corrects impaired mucosal IgA responses toward the FluMist vaccine in vitamin A deficient animals. • Results encourage analysis and correction of respiratory virus vaccine-induced IgA responses in humans suffering from vitamin A deficiencies. |
| doi_str_mv | 10.1016/j.vaccine.2014.03.025 |
| format | Article |
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Psychology ; humans ; immune response ; Immunity, Mucosal ; immunoglobulin A ; Immunoglobulin A - immunology ; Infectious diseases ; Influenza ; Influenza Vaccines - immunology ; Influenza virus ; Mice ; Mice, Inbred C57BL ; Microbiology ; Miscellaneous ; Morbidity ; Mortality ; Mucosal IgA ; Oral ; Orthomyxoviridae ; Paramyxovirus ; pathogens ; Pregnancy ; Public health ; respiratory system ; Respiratory tract ; Retinoic acid ; Retinyl palmitate ; Tretinoin - pharmacology ; vaccination ; Vaccination - methods ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral infections ; Virology ; Vitamin A ; Vitamin A - analogs & derivatives ; Vitamin A - pharmacology ; vitamin A deficiency ; Vitamin A Deficiency - immunology</subject><ispartof>Vaccine, 2014-05, Vol.32 (22), p.2521-2524</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited May 7, 2014</rights><rights>2014 Elsevier Ltd. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c646t-e0593e06ddff81dce61a90d3bb3a4796071519834e1964db66e1799bd03598683</citedby><cites>FETCH-LOGICAL-c646t-e0593e06ddff81dce61a90d3bb3a4796071519834e1964db66e1799bd03598683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X14003697$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28423964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24657715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Surman, S.L</creatorcontrib><creatorcontrib>Jones, B.G</creatorcontrib><creatorcontrib>Sealy, R.E</creatorcontrib><creatorcontrib>Rudraraju, R</creatorcontrib><creatorcontrib>Hurwitz, J.L</creatorcontrib><title>Oral retinyl palmitate or retinoic acid corrects mucosal IgA responses toward an intranasal influenza virus vaccine in vitamin A deficient mice</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • The mucosal IgA response to the influenza virus FluMist vaccine is impaired in vitamin A deficient animals. • Retinyl palmitate corrects impaired mucosal IgA responses toward the FluMist vaccine in vitamin A deficient animals. • Retinoic acid corrects impaired mucosal IgA responses toward the FluMist vaccine in vitamin A deficient animals. • Results encourage analysis and correction of respiratory virus vaccine-induced IgA responses in humans suffering from vitamin A deficiencies.</description><subject>Administration, Intranasal</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>antibodies</subject><subject>Antibody forming cells</subject><subject>Antibody-Producing Cells - immunology</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Children & youth</subject><subject>clinical trials</subject><subject>Female</subject><subject>FluMist</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>humans</topic><topic>immune response</topic><topic>Immunity, Mucosal</topic><topic>immunoglobulin A</topic><topic>Immunoglobulin A - immunology</topic><topic>Infectious diseases</topic><topic>Influenza</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza virus</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Mucosal IgA</topic><topic>Oral</topic><topic>Orthomyxoviridae</topic><topic>Paramyxovirus</topic><topic>pathogens</topic><topic>Pregnancy</topic><topic>Public health</topic><topic>respiratory system</topic><topic>Respiratory tract</topic><topic>Retinoic acid</topic><topic>Retinyl palmitate</topic><topic>Tretinoin - pharmacology</topic><topic>vaccination</topic><topic>Vaccination - methods</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Viral infections</topic><topic>Virology</topic><topic>Vitamin A</topic><topic>Vitamin A - 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| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2014-05, Vol.32 (22), p.2521-2524 |
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| language | eng |
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| subjects | Administration, Intranasal Allergy and Immunology Animals antibodies Antibody forming cells Antibody-Producing Cells - immunology Applied microbiology Biological and medical sciences Children & youth clinical trials Female FluMist Fundamental and applied biological sciences. Psychology humans immune response Immunity, Mucosal immunoglobulin A Immunoglobulin A - immunology Infectious diseases Influenza Influenza Vaccines - immunology Influenza virus Mice Mice, Inbred C57BL Microbiology Miscellaneous Morbidity Mortality Mucosal IgA Oral Orthomyxoviridae Paramyxovirus pathogens Pregnancy Public health respiratory system Respiratory tract Retinoic acid Retinyl palmitate Tretinoin - pharmacology vaccination Vaccination - methods Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral infections Virology Vitamin A Vitamin A - analogs & derivatives Vitamin A - pharmacology vitamin A deficiency Vitamin A Deficiency - immunology |
| title | Oral retinyl palmitate or retinoic acid corrects mucosal IgA responses toward an intranasal influenza virus vaccine in vitamin A deficient mice |
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