Gamma ray sterilization of delta inulin adjuvant particles (Advax™) makes minor, partly reversible structural changes without affecting adjuvant activity
Highlights • Advax™ adjuvant (delta inulin-based) has uniform particles ∼1–2 μm diameter. • Microparticles of this size cannot be terminally sterile-filtered. •60 Co sterilization (25 kGy) does not overtly affect adjuvant action or structure. • Isoform and reducing-end analyses show single-hit cleav...
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| Veröffentlicht in: | Vaccine 2014-01, Vol.32 (5), p.552-557 |
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| creator | Cooper, P.D Barclay, T.G Ginic-Markovic, M Petrovsky, N |
| description | Highlights • Advax™ adjuvant (delta inulin-based) has uniform particles ∼1–2 μm diameter. • Microparticles of this size cannot be terminally sterile-filtered. •60 Co sterilization (25 kGy) does not overtly affect adjuvant action or structure. • Isoform and reducing-end analyses show single-hit cleavage of some inulin chains. • Gamma irradiation appears as a viable strategy for Advax™ terminal sterilization. |
| doi_str_mv | 10.1016/j.vaccine.2013.11.105 |
| format | Article |
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Psychology ; Gamma Rays ; Glucose ; Immunity ; Immunization ; Inulin ; Inulin - chemistry ; Mice ; Mice, Inbred BALB C ; Microbiology ; Physical properties ; Polymorph ; Protein Isoforms - chemistry ; Sterilization ; Sterilization - methods ; Temperature ; Vaccine ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2014-01, Vol.32 (5), p.552-557</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 23, 2014</rights><rights>2013 Elsevier Ltd. 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| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2014-01, Vol.32 (5), p.552-557 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Adjuvant Adjuvants, Immunologic - chemistry Allergy and Immunology Animals Antigens Applied microbiology Atoms & subatomic particles Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Gamma Rays Glucose Immunity Immunization Inulin Inulin - chemistry Mice Mice, Inbred BALB C Microbiology Physical properties Polymorph Protein Isoforms - chemistry Sterilization Sterilization - methods Temperature Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Gamma ray sterilization of delta inulin adjuvant particles (Advax™) makes minor, partly reversible structural changes without affecting adjuvant activity |
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