HIV-associated anemia after 96 weeks on therapy: determinants across age ranges in Uganda and Zimbabwe

Given the detrimental effects of HIV-associated anemia on morbidity, we determined factors associated with anemia after 96 weeks of antiretroviral therapy (ART) across age groups. An HIV-positive cohort (n=3,580) of children age 5-14, reproductive age adults 18-49, and older adults ≥50 from two rand...

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Veröffentlicht in:	AIDS research and human retroviruses 2014-06, Vol.30 (6), p.523-530
Hauptverfasser:	Jaganath, Devan, Walker, A Sarah, Ssali, Francis, Musiime, Victor, Kiweewa, Francis, Kityo, Cissy, Salata, Robert, Mugyenyi, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Aged, 80 and over Anemia - epidemiology Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Child Child, Preschool Cohort Studies Epidemiology Female HIV Infections - complications HIV Infections - drug therapy Human immunodeficiency virus Humans Male Middle Aged Prevalence Randomized Controlled Trials as Topic Retrovirus Sex Factors Time Factors Uganda - epidemiology Young Adult Zimbabwe - epidemiology
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Zusammenfassung:	Given the detrimental effects of HIV-associated anemia on morbidity, we determined factors associated with anemia after 96 weeks of antiretroviral therapy (ART) across age groups. An HIV-positive cohort (n=3,580) of children age 5-14, reproductive age adults 18-49, and older adults ≥50 from two randomized trials in Uganda and Zimbabwe were evaluated from initiation of therapy through 96 weeks. We conducted logistic and multinomial regression to evaluate common and differential determinants for anemia at 96 weeks on therapy. Prior to initiation of ART, the prevalence of anemia (age 5-11
ISSN:	0889-2229 1931-8405
DOI:	10.1089/aid.2013.0255