The impact of age and CYP2C9 and VKORC1 variants on stable warfarin dose in the paediatric population

The impact of age and CYP2C9 and VKORC1 variants on stable warfarin dose in the paediatric population

Summary The influence of genetic variation on warfarin dose requirement is limited for paediatric patients. We performed a retrospective, cross‐sectional study to examine the effect of variant CYP2C9 and VKORC1 genotypes on warfarin dose in 100 children. Those with VKORC1 genotype AA required 48% of...

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Veröffentlicht in:British journal of haematology 2014-06, Vol.165 (6), p.832-835
Hauptverfasser: Vear, Susan I., Ayers, Gregory D., Driest, Sara L., Sidonio, Robert F., Stein, Charles Michael, Ho, Richard H.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Age Factors
Alleles
Anticoagulants - administration & dosage
Aryl Hydrocarbon Hydroxylases - genetics
Biological and medical sciences
Child
Child, Preschool
Cross-Sectional Studies
CYP2C9
Cytochrome P-450 CYP2C9
Genetic Variation
Genotype
Hematologic and hematopoietic diseases
Humans
Infant
Medical sciences
paediatrics
Pharmacogenetics
pharmacogenomics
Retrospective Studies
Tumors
Vitamin K Epoxide Reductases - genetics
VKORC1
warfarin
Warfarin - administration & dosage
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Zusammenfassung:Summary The influence of genetic variation on warfarin dose requirement is limited for paediatric patients. We performed a retrospective, cross‐sectional study to examine the effect of variant CYP2C9 and VKORC1 genotypes on warfarin dose in 100 children. Those with VKORC1 genotype AA required 48% of the dose of homozygous wild‐type (GG, P 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.12817