Human cathelicidin LL-37 resistance and increased daptomycin MIC in methicillin-resistant Staphylococcus aureus strain USA600 (ST45) are associated with increased mortality in a hospital setting

Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virule...

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Veröffentlicht in:	Journal of clinical microbiology 2014-06, Vol.52 (6), p.2172-2174
Hauptverfasser:	Sakoulas, George, Guram, Kripa, Reyes, Katherine, Nizet, Victor, Zervos, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides - pharmacology Bacteremia - microbiology Bacteremia - mortality Cross Infection - microbiology Cross Infection - mortality Daptomycin - pharmacology Drug Resistance, Bacterial Epidemiology Hospitals Humans Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbial Sensitivity Tests Microbial Viability - drug effects Staphylococcal Infections - microbiology Staphylococcal Infections - mortality Staphylococcus aureus United States
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Zusammenfassung:	Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virulent health care-associated MRSA strains may coevolve innate host defense peptide and antibiotic resistances.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00189-14