Fungal DNA detected in blood samples of patients who received contaminated methylprednisolone injections reveals increased complexity of causative agents

Using Exserohilum rostratum-specific and panfungal real-time PCR, we studied 24 blood samples and 2 synovial fluid specimens from 20 patients with persistent or worsening pain following injections of contaminated methylprednisolone. Seven blood specimens from 6 patients were significantly positive f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical microbiology 2014-06, Vol.52 (6), p.2212-2215
Hauptverfasser:	Zhao, Yanan, Armeanu, Emilian, DiVerniero, Richard, Lewis, Terri A, Dobson, Richard C, Kontoyiannis, Dimitrios P, Roilides, Emmanuel, Walsh, Thomas J, Perlin, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood - microbiology DNA, Fungal - genetics Drug Contamination Female Fungemia - chemically induced Fungi - classification Fungi - isolation & purification Genetic Variation Humans Iatrogenic Disease Injections, Intravenous Male Methylprednisolone - administration & dosage Middle Aged Mycology Real-Time Polymerase Chain Reaction Synovial Fluid - microbiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Using Exserohilum rostratum-specific and panfungal real-time PCR, we studied 24 blood samples and 2 synovial fluid specimens from 20 patients with persistent or worsening pain following injections of contaminated methylprednisolone. Seven blood specimens from 6 patients were significantly positive for fungal DNA by panfungal PCR, with multiple fungal species identified.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00854-14