Anthrax lethal and edema toxins in anthrax pathogenesis

Highlights • CMG2 is the physiologically-relevant receptor for anthrax toxins in vivo. • Targeting of innate immunity by the toxins is essential for initiation of infection. • Anthrax toxins directly induce lethality at the terminal stage of infection. • The cardiovascular system and liver are major...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2014-06, Vol.22 (6), p.317-325
Hauptverfasser:	Liu, Shihui, Moayeri, Mahtab, Leppla, Stephen H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anthrax Anthrax - drug therapy Anthrax - microbiology Antigens, Bacterial - metabolism Antigens, Bacterial - physiology Bacillus anthracis - metabolism Bacillus anthracis - pathogenicity Bacterial Toxins - metabolism capillary morphogenesis protein 2 edema toxin Host-Pathogen Interactions Humans Internal Medicine lethal toxin Mice Models, Biological Receptors, Peptide - metabolism tumor endothelial marker 8
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Beschreibung
Zusammenfassung:	Highlights • CMG2 is the physiologically-relevant receptor for anthrax toxins in vivo. • Targeting of innate immunity by the toxins is essential for initiation of infection. • Anthrax toxins directly induce lethality at the terminal stage of infection. • The cardiovascular system and liver are major targets for anthrax toxins.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2014.02.012