Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have rev...
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Veröffentlicht in: | Cell 2014-02, Vol.156 (4), p.633-648 |
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creator | West, Anthony P. Scharf, Louise Scheid, Johannes F. Klein, Florian Bjorkman, Pamela J. Nussenzweig, Michel C. |
description | Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection. |
doi_str_mv | 10.1016/j.cell.2014.01.052 |
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However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2014.01.052</identifier><identifier>PMID: 24529371</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>AIDS Vaccines - immunology ; AIDS Vaccines - therapeutic use ; Animals ; antibodies ; Antibodies, Neutralizing - chemistry ; Antibodies, Neutralizing - immunology ; env Gene Products, Human Immunodeficiency Virus - chemistry ; env Gene Products, Human Immunodeficiency Virus - immunology ; HIV Antibodies - chemistry ; HIV Antibodies - immunology ; HIV infections ; HIV Infections - immunology ; HIV Infections - prevention & control ; HIV-1 ; Human immunodeficiency virus 1 ; Humans ; Immunotherapy ; Macaca ; mice ; therapeutics ; vaccine development ; vaccines</subject><ispartof>Cell, 2014-02, Vol.156 (4), p.633-648</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. 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However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.</description><subject>AIDS Vaccines - immunology</subject><subject>AIDS Vaccines - therapeutic use</subject><subject>Animals</subject><subject>antibodies</subject><subject>Antibodies, Neutralizing - chemistry</subject><subject>Antibodies, Neutralizing - immunology</subject><subject>env Gene Products, Human Immunodeficiency Virus - chemistry</subject><subject>env Gene Products, Human Immunodeficiency Virus - immunology</subject><subject>HIV Antibodies - chemistry</subject><subject>HIV Antibodies - immunology</subject><subject>HIV infections</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - prevention & control</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Macaca</subject><subject>mice</subject><subject>therapeutics</subject><subject>vaccine development</subject><subject>vaccines</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYModlv9Aj5IHn2ZaW4mmT8gQinarhSEtvY1JJk73SyzyZpkCv32zrBt0Rd9upD7O4ebcwj5AKwEBvXptrQ4jiVnIEoGJZP8FVkB65pCQMNfkxVjHS_auhFH5DilLWOslVK-JUdcSN5VDazI95scJ5unqEe69sndb3KiwdO8QXodRqRhoGc-OxN6h4k6Ty_XdwXQO22t80i17-ntBqPeP74jbwY9Jnz_NE_Iz29fb88vi6sfF-vzs6vCSilyYQch-gEZ1xJaHKTpoLK2MsbyGgyvbF9xw6VhbV3JtqlbzZdX00MNsm376oR8OfjuJ7PD3qLP8_VqH91Ox0cVtFN_b7zbqPvwoAQTUHM5G3x6Mojh14Qpq51LS5TaY5iS4nNQHOpOwn9RkABV1wCvZ5QfUBtDShGHl4uAqaUvtVWLUi19KQZq7msWffzzLy-S54Jm4PMBwDnRB4dRJevQW-xdRJtVH9y__H8D_4al3g</recordid><startdate>20140213</startdate><enddate>20140213</enddate><creator>West, Anthony P.</creator><creator>Scharf, Louise</creator><creator>Scheid, Johannes F.</creator><creator>Klein, Florian</creator><creator>Bjorkman, Pamela J.</creator><creator>Nussenzweig, Michel C.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20140213</creationdate><title>Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy</title><author>West, Anthony P. ; 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However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24529371</pmid><doi>10.1016/j.cell.2014.01.052</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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subjects | AIDS Vaccines - immunology AIDS Vaccines - therapeutic use Animals antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology env Gene Products, Human Immunodeficiency Virus - chemistry env Gene Products, Human Immunodeficiency Virus - immunology HIV Antibodies - chemistry HIV Antibodies - immunology HIV infections HIV Infections - immunology HIV Infections - prevention & control HIV-1 Human immunodeficiency virus 1 Humans Immunotherapy Macaca mice therapeutics vaccine development vaccines |
title | Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy |
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