Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy

Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have rev...

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Veröffentlicht in:Cell 2014-02, Vol.156 (4), p.633-648
Hauptverfasser: West, Anthony P., Scharf, Louise, Scheid, Johannes F., Klein, Florian, Bjorkman, Pamela J., Nussenzweig, Michel C.
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container_end_page 648
container_issue 4
container_start_page 633
container_title Cell
container_volume 156
creator West, Anthony P.
Scharf, Louise
Scheid, Johannes F.
Klein, Florian
Bjorkman, Pamela J.
Nussenzweig, Michel C.
description Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.
doi_str_mv 10.1016/j.cell.2014.01.052
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subjects AIDS Vaccines - immunology
AIDS Vaccines - therapeutic use
Animals
antibodies
Antibodies, Neutralizing - chemistry
Antibodies, Neutralizing - immunology
env Gene Products, Human Immunodeficiency Virus - chemistry
env Gene Products, Human Immunodeficiency Virus - immunology
HIV Antibodies - chemistry
HIV Antibodies - immunology
HIV infections
HIV Infections - immunology
HIV Infections - prevention & control
HIV-1
Human immunodeficiency virus 1
Humans
Immunotherapy
Macaca
mice
therapeutics
vaccine development
vaccines
title Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
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