FRET-enabled biological characterization of polymeric micelles
Abstract Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FR...
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| Veröffentlicht in: | Biomaterials 2014-04, Vol.35 (11), p.3489-3496 |
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| container_end_page | 3496 |
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| container_issue | 11 |
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| container_title | Biomaterials |
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| creator | Morton, Stephen W Zhao, Xiaoyong Quadir, Mohiuddin A Hammond, Paula T |
| description | Abstract Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FRET). This characterization method allows for exquisite insight into the fate of micellar constituents, affording the capabilities to rapidly and efficiently evaluate a library of synthetically derived micellar systems as new therapeutic platforms in vivo . FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management. |
| doi_str_mv | 10.1016/j.biomaterials.2014.01.027 |
| format | Article |
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In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FRET). This characterization method allows for exquisite insight into the fate of micellar constituents, affording the capabilities to rapidly and efficiently evaluate a library of synthetically derived micellar systems as new therapeutic platforms in vivo . FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2014.01.027</identifier><identifier>PMID: 24477190</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Animals ; Delivery ; Dentistry ; Female ; Fluorescence Resonance Energy Transfer - methods ; Fluorescent Dyes - metabolism ; FRET ; In vivo stability ; Light ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Micelle ; Micelles ; Polymers - chemistry ; Scattering, Radiation ; Self-assembly ; Tissue Distribution</subject><ispartof>Biomaterials, 2014-04, Vol.35 (11), p.3489-3496</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. 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FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Delivery</subject><subject>Dentistry</subject><subject>Female</subject><subject>Fluorescence Resonance Energy Transfer - methods</subject><subject>Fluorescent Dyes - metabolism</subject><subject>FRET</subject><subject>In vivo stability</subject><subject>Light</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Micelle</subject><subject>Micelles</subject><subject>Polymers - chemistry</subject><subject>Scattering, Radiation</subject><subject>Self-assembly</subject><subject>Tissue Distribution</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUdtO3DAQtaqisgV-AUW8J53x5rLhAani0lZCQmrps-WMJ-DFiVd2QFq-HgdaRPvEk2XPnIvPEeIIoUDA-su66Kwf9MTBahcLCVgWgAXI5oNY4KpZ5VUL1UexSAOZtzXKXfE5xjWkO5Tyk9iVZdk02MJCnFz8PL_OedSdY5MlXudvLGmX0a0OmmaNRz1ZP2a-zzbebYf0QtlgiZ3juC92-uSBD_6ce-L3xfn16ff88urbj9OvlzlVpZxyMgTSULesSqolmFLXnaGeuNGdxFID6hpMS6ZiSN5WABUusdf9ijtsUC73ktFn3s19N7AhHqegndoEO-iwVV5b9e9ktLfqxj-o9GFIqong-IWAgo8xcP-KRVBzqmqt3qaq5lQVoEqpJvDhW_VX6N8Y08LZywKnDB4sBxXJ8khsbGCalPH2fTon_9GQs-Ncxx1vOa79fRhnDKooFahfc79zvalWANlWyyfp8KbX</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Morton, Stephen W</creator><creator>Zhao, Xiaoyong</creator><creator>Quadir, Mohiuddin A</creator><creator>Hammond, Paula T</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140401</creationdate><title>FRET-enabled biological characterization of polymeric micelles</title><author>Morton, Stephen W ; Zhao, Xiaoyong ; Quadir, Mohiuddin A ; Hammond, Paula T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-cdc02dcb354c620d4a6bdcfce7ab214a01a60d9cd5e02448005131faf8eb17123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Delivery</topic><topic>Dentistry</topic><topic>Female</topic><topic>Fluorescence Resonance Energy Transfer - methods</topic><topic>Fluorescent Dyes - metabolism</topic><topic>FRET</topic><topic>In vivo stability</topic><topic>Light</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Micelle</topic><topic>Micelles</topic><topic>Polymers - chemistry</topic><topic>Scattering, Radiation</topic><topic>Self-assembly</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morton, Stephen W</creatorcontrib><creatorcontrib>Zhao, Xiaoyong</creatorcontrib><creatorcontrib>Quadir, Mohiuddin A</creatorcontrib><creatorcontrib>Hammond, Paula T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morton, Stephen W</au><au>Zhao, Xiaoyong</au><au>Quadir, Mohiuddin A</au><au>Hammond, Paula T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FRET-enabled biological characterization of polymeric micelles</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>35</volume><issue>11</issue><spage>3489</spage><epage>3496</epage><pages>3489-3496</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. 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| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2014-04, Vol.35 (11), p.3489-3496 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4040354 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Advanced Basic Science Animals Delivery Dentistry Female Fluorescence Resonance Energy Transfer - methods Fluorescent Dyes - metabolism FRET In vivo stability Light Mice Mice, Inbred BALB C Mice, Nude Micelle Micelles Polymers - chemistry Scattering, Radiation Self-assembly Tissue Distribution |
| title | FRET-enabled biological characterization of polymeric micelles |
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