The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning
Highlights • First demonstration that deletion of a DCV protein profoundly impairs active avoidance learning. • Deletion of both copies of the IA-2 gene is required to impair active avoidance learning. • The deletion of IA-2 results in decreased phosphorylation of CREB and CAMKII in the brain. • GBR...
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| Veröffentlicht in: | Neuroscience 2014-06, Vol.269, p.35-42 |
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| creator | Carmona, G.N Nishimura, T Schindler, C.W Panlilio, L.V Notkins, A.L |
| description | Highlights • First demonstration that deletion of a DCV protein profoundly impairs active avoidance learning. • Deletion of both copies of the IA-2 gene is required to impair active avoidance learning. • The deletion of IA-2 results in decreased phosphorylation of CREB and CAMKII in the brain. • GBR12909 increases the phosphorylation of CREB and CAMKII and restores active avoidance learning. • We conclude that in the absence of the IA-2 gene active avoidance learning is impaired. |
| doi_str_mv | 10.1016/j.neuroscience.2014.03.023 |
| format | Article |
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Impaired glucose tolerance</subject><subject>dopamine</subject><subject>Dopamine Uptake Inhibitors - pharmacology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fundamental and applied biological sciences. 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Impaired glucose tolerance</topic><topic>dopamine</topic><topic>Dopamine Uptake Inhibitors - pharmacology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Neuroscience, 2014-06, Vol.269, p.35-42 |
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| subjects | Animals autoantigens Avoidance Learning - drug effects Avoidance Learning - physiology Biological and medical sciences Blotting, Western Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism CAMKII Corpus Striatum - drug effects Corpus Striatum - physiology CREB Cyclic AMP Response Element-Binding Protein - metabolism Diabetes. Impaired glucose tolerance dopamine Dopamine Uptake Inhibitors - pharmacology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Heterozygote Hippocampus - drug effects Hippocampus - physiology Homozygote Male Medical sciences Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Neurology Phosphorylation - drug effects Phosphorylation - physiology Piperazines - pharmacology Receptor-Like Protein Tyrosine Phosphatases, Class 8 - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 8 - metabolism Species Specificity type-1 diabetes Vertebrates: nervous system and sense organs |
| title | The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning |
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