Phase I clinical trial of O -acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine
Highlights • A semi-synthetic typhoid conjugate vaccine. • Phase I of pectin based typhoid vaccine. • safe and immunogenic in adult volunteers.
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| Veröffentlicht in: | Vaccine 2014-05, Vol.32 (22), p.2618-2622 |
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| container_end_page | 2622 |
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| container_issue | 22 |
| container_start_page | 2618 |
| container_title | Vaccine |
| container_volume | 32 |
| creator | Szu, Shousun C Lin, Kimi F.-Y Hunt, Steven Chu, Chiayung Thinh, Nguyen Duc |
| description | Highlights • A semi-synthetic typhoid conjugate vaccine. • Phase I of pectin based typhoid vaccine. • safe and immunogenic in adult volunteers. |
| doi_str_mv | 10.1016/j.vaccine.2014.03.023 |
| format | Article |
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Psychology</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Male</topic><topic>Microbiology</topic><topic>Pectins - immunology</topic><topic>Phase I pectin-based</topic><topic>Plant polysaccharide</topic><topic>Polysaccharides, Bacterial - adverse effects</topic><topic>Polysaccharides, Bacterial - therapeutic use</topic><topic>Recombinant Proteins - immunology</topic><topic>Safety immunogenicity</topic><topic>Semi-synthetic</topic><topic>Typhoid conjugate vaccine</topic><topic>Typhoid Fever - prevention & control</topic><topic>Typhoid-Paratyphoid Vaccines - adverse effects</topic><topic>Typhoid-Paratyphoid Vaccines - therapeutic use</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, Conjugate - therapeutic use</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szu, Shousun C</creatorcontrib><creatorcontrib>Lin, Kimi F.-Y</creatorcontrib><creatorcontrib>Hunt, Steven</creatorcontrib><creatorcontrib>Chu, Chiayung</creatorcontrib><creatorcontrib>Thinh, Nguyen Duc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szu, Shousun C</au><au>Lin, Kimi F.-Y</au><au>Hunt, Steven</au><au>Chu, Chiayung</au><au>Thinh, Nguyen Duc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase I clinical trial of O -acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2014-05-07</date><risdate>2014</risdate><volume>32</volume><issue>22</issue><spage>2618</spage><epage>2622</epage><pages>2618-2622</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Highlights • A semi-synthetic typhoid conjugate vaccine. • Phase I of pectin based typhoid vaccine. • safe and immunogenic in adult volunteers.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24657719</pmid><doi>10.1016/j.vaccine.2014.03.023</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-2884-9201</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2014-05, Vol.32 (22), p.2618-2622 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4034380 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Acetylation Adolescent Adult Allergy and Immunology Antibodies, Bacterial - blood Applied microbiology Biological and medical sciences Citrus Citrus - chemistry Female Fundamental and applied biological sciences. Psychology Humans Immunoglobulin G - blood Male Microbiology Pectins - immunology Phase I pectin-based Plant polysaccharide Polysaccharides, Bacterial - adverse effects Polysaccharides, Bacterial - therapeutic use Recombinant Proteins - immunology Safety immunogenicity Semi-synthetic Typhoid conjugate vaccine Typhoid Fever - prevention & control Typhoid-Paratyphoid Vaccines - adverse effects Typhoid-Paratyphoid Vaccines - therapeutic use Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Conjugate - therapeutic use Young Adult |
| title | Phase I clinical trial of O -acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine |
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