Phase I clinical trial of O -acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine

Highlights • A semi-synthetic typhoid conjugate vaccine. • Phase I of pectin based typhoid vaccine. • safe and immunogenic in adult volunteers.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2014-05, Vol.32 (22), p.2618-2622
Hauptverfasser:	Szu, Shousun C, Lin, Kimi F.-Y, Hunt, Steven, Chu, Chiayung, Thinh, Nguyen Duc
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adolescent Adult Allergy and Immunology Antibodies, Bacterial - blood Applied microbiology Biological and medical sciences Citrus Citrus - chemistry Female Fundamental and applied biological sciences. Psychology Humans Immunoglobulin G - blood Male Microbiology Pectins - immunology Phase I pectin-based Plant polysaccharide Polysaccharides, Bacterial - adverse effects Polysaccharides, Bacterial - therapeutic use Recombinant Proteins - immunology Safety immunogenicity Semi-synthetic Typhoid conjugate vaccine Typhoid Fever - prevention & control Typhoid-Paratyphoid Vaccines - adverse effects Typhoid-Paratyphoid Vaccines - therapeutic use Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Conjugate - therapeutic use Young Adult
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Beschreibung
Zusammenfassung:	Highlights • A semi-synthetic typhoid conjugate vaccine. • Phase I of pectin based typhoid vaccine. • safe and immunogenic in adult volunteers.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.03.023