Chronic tooth pulp inflammation induces persistent expression of phosphorylated ERK (pERK) and phosphorylated p38 (pp38) in trigeminal subnucleus caudalis

Highlights • Chronic inflammation of tooth pulp activates pERK and pp38 in the trigeminal nucleus • Activation is persistent and bilateral, and further increased by acute stimulation • This altered signaling may be relevant in the development of chronic pulpitic pain • pERK and pp38 are more sensiti...

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Veröffentlicht in:	Neuroscience 2014-06, Vol.269 (100), p.318-330
Hauptverfasser:	Worsley, M.A, Allen, C.E, Billinton, A, King, A.E, Boissonade, F.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - physiology Biological and medical sciences Cell Count chronic inflammation Chronic Pain - etiology Chronic Pain - physiopathology Dental Pulp - physiopathology Disease Models, Animal Extracellular Signal-Regulated MAP Kinases - metabolism Female Ferrets Fundamental and applied biological sciences. Psychology Immunohistochemistry MAPK Microscopy, Fluorescence Neurology Neurons - physiology p38 Mitogen-Activated Protein Kinases - metabolism pain pERK Phosphorylation Photomicrography Physical Stimulation pp38 Proto-Oncogene Proteins c-fos - metabolism Pulpitis - complications Pulpitis - physiopathology Trigeminal Caudal Nucleus - physiopathology trigeminal nucleus Vertebrates: nervous system and sense organs
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