Chronic tooth pulp inflammation induces persistent expression of phosphorylated ERK (pERK) and phosphorylated p38 (pp38) in trigeminal subnucleus caudalis

Chronic tooth pulp inflammation induces persistent expression of phosphorylated ERK (pERK) and phosphorylated p38 (pp38) in trigeminal subnucleus caudalis

Highlights • Chronic inflammation of tooth pulp activates pERK and pp38 in the trigeminal nucleus • Activation is persistent and bilateral, and further increased by acute stimulation • This altered signaling may be relevant in the development of chronic pulpitic pain • pERK and pp38 are more sensiti...

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Veröffentlicht in:Neuroscience 2014-06, Vol.269 (100), p.318-330
Hauptverfasser: Worsley, M.A, Allen, C.E, Billinton, A, King, A.E, Boissonade, F.M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Astrocytes - physiology
Biological and medical sciences
Cell Count
chronic inflammation
Chronic Pain - etiology
Chronic Pain - physiopathology
Dental Pulp - physiopathology
Disease Models, Animal
Extracellular Signal-Regulated MAP Kinases - metabolism
Female
Ferrets
Fundamental and applied biological sciences. Psychology
Immunohistochemistry
MAPK
Microscopy, Fluorescence
Neurology
Neurons - physiology
p38 Mitogen-Activated Protein Kinases - metabolism
pain
pERK
Phosphorylation
Photomicrography
Physical Stimulation
pp38
Proto-Oncogene Proteins c-fos - metabolism
Pulpitis - complications
Pulpitis - physiopathology
Trigeminal Caudal Nucleus - physiopathology
trigeminal nucleus
Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:Highlights • Chronic inflammation of tooth pulp activates pERK and pp38 in the trigeminal nucleus • Activation is persistent and bilateral, and further increased by acute stimulation • This altered signaling may be relevant in the development of chronic pulpitic pain • pERK and pp38 are more sensitive markers of central change than Fos expression • Sequential activation in different cell types may be linked to pain progression
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.03.056