Using Network Biology to Bridge Pharmacokinetics and Pharmacodynamics in Oncology

If mathematical modeling is to be used effectively in cancer drug development, future models must take into account both the mechanistic details of cellular signal transduction networks and the pharmacokinetics (PK) of drugs used to inhibit their oncogenic activity. In this perspective, we present a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:CPT: pharmacometrics and systems pharmacology 2013-09, Vol.2 (9), p.1-7
Hauptverfasser: Kirouac, DC, Onsum, MD
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:If mathematical modeling is to be used effectively in cancer drug development, future models must take into account both the mechanistic details of cellular signal transduction networks and the pharmacokinetics (PK) of drugs used to inhibit their oncogenic activity. In this perspective, we present an approach to building multiscale models that capture systems‐level architectural features of oncogenic signaling networks, and describe how these models can be used to design combination therapies and identify predictive biomarkers in silico. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e71; doi:10.1038/psp.2013.38; published online 4 September 2013
ISSN:2163-8306
2163-8306
DOI:10.1038/psp.2013.38