Stereocontrol in Palladium-Catalyzed Propargylic Substitutions: Kinetic Resolution to give Enantioenriched 1,5-Enynes and Propargyl Acetates

Stereocontrol in Palladium-Catalyzed Propargylic Substitutions: Kinetic Resolution to give Enantioenriched 1,5-Enynes and Propargyl Acetates

Kinetic resolution during the catalytic allyl‐propargyl cross‐coupling with chiral starting materials can be accomplished with a chiral palladium catalyst. These reactions offer ready access to enantiomerically enriched enyne products from simple, readily available starting materials.

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Veröffentlicht in:Advanced synthesis & catalysis 2013-11, Vol.355 (17), p.3413-3419
Hauptverfasser: Ardolino, Michael J., Eno, Meredith S., Morken, James P.
Format: Artikel
Sprache:eng
Schlagworte:
Acetates
allylation
asymmetric catalysis
asymmetric synthesis
boron
palladium
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Zusammenfassung:Kinetic resolution during the catalytic allyl‐propargyl cross‐coupling with chiral starting materials can be accomplished with a chiral palladium catalyst. These reactions offer ready access to enantiomerically enriched enyne products from simple, readily available starting materials.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201300720