Preparation, Gram-Negative Antibacterial Activity, and Hydrolytic Stability of Novel Siderophore-Conjugated Monocarbam Diols

Preparation, Gram-Negative Antibacterial Activity, and Hydrolytic Stability of Novel Siderophore-Conjugated Monocarbam Diols

A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure−activity relationships associated with the in vitro and in vivo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACS medicinal chemistry letters 2011-05, Vol.2 (5), p.385-390
Hauptverfasser: Flanagan, Mark E, Brickner, Steven J, Lall, Manjinder, Casavant, Jeffrey, Deschenes, Laura, Finegan, Steven M, George, David M, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Hoang, Thuy, Lamb, Lucinda, Marra, Andrea, Mitton-Fry, Mark, Mueller, John P, Mullins, Lisa M, Noe, Mark C, O'Donnell, John P, Pattavina, David, Penzien, Joseph B, Schuff, Brandon P, Sun, Jianmin, Whipple, David A, Young, Jennifer, Gootz, Thomas D
Format: Artikel
Sprache:eng
Schlagworte:
Letter
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure−activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.
ISSN:1948-5875
1948-5875
DOI:10.1021/ml200012f