Stereochemical lability of azatitanacyclopropanes: dynamic kinetic resolution in reductive cross-coupling reactions with allylic alcohols

Azatitanacyclopropanes (titanaziridines) are shown to be stereochemically labile under reaction conditions for reductive cross-coupling. This fundamental property has been employed to realize highly selective asymmetric coupling reactions with allylic alcohols that proceed by dynamic kinetic resolut...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (78), p.8857-8859
Hauptverfasser:	Yang, Dexi, Micalizio, Glenn C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aza Compounds - chemistry Aziridines - chemistry Cyclopropanes - chemistry Oxidation-Reduction Propanols - chemistry Stereoisomerism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Azatitanacyclopropanes (titanaziridines) are shown to be stereochemically labile under reaction conditions for reductive cross-coupling. This fundamental property has been employed to realize highly selective asymmetric coupling reactions with allylic alcohols that proceed by dynamic kinetic resolution.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc45607b