Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women

Osteoporosis is a highly heritable trait. Among the genes associated with bone mineral density (BMD), the low-density lipoprotein receptor-related protein 5 gene (LRP5) has been consistently identified in Caucasians. However LRP5 contribution to osteoporosis in populations of other ethnicities remai...

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Veröffentlicht in:	BMC musculoskeletal disorders 2014-04, Vol.15 (1), p.144-144, Article 144
Hauptverfasser:	Sassi, Rim, Sahli, Hela, Souissi, Chiraz, El Mahmoudi, Hejer, Zouari, Bechir, Ben Ammar ElGaaied, Amel, Sellami, Slaheddine, Ferrari, Serge Livio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bone density Bone Density - genetics Female Fractures Genetic Association Studies - methods Genotype Hormone replacement therapy Humans Low Density Lipoprotein Receptor-Related Protein-5 - genetics Lumbar Vertebrae - pathology Lumbar Vertebrae - physiology Middle Aged Musculoskeletal diseases Older people Osteoporosis Osteoporosis, Postmenopausal - diagnosis Osteoporosis, Postmenopausal - epidemiology Osteoporosis, Postmenopausal - genetics Polymorphism, Single Nucleotide - genetics Prospective Studies Tunisia - epidemiology
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Zusammenfassung:	Osteoporosis is a highly heritable trait. Among the genes associated with bone mineral density (BMD), the low-density lipoprotein receptor-related protein 5 gene (LRP5) has been consistently identified in Caucasians. However LRP5 contribution to osteoporosis in populations of other ethnicities remains poorly known. To determine whether LRP5 polymorphisms Ala1330Val and Val667Met are associated with BMD in North Africans, these genotypes were analyzed in 566 post-menopausal Tunisian women with mean age of 59.5 ± 7 .7 years, of which 59.1% have low bone mass (T-score
ISSN:	1471-2474 1471-2474
DOI:	10.1186/1471-2474-15-144