Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression

Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression

Despite recent advancements in “omic” technologies, personalized medicine has not realized its fullest potential due to isolated and incomplete application of gene expression tools. In many instances, pharmacogenomics is being interchangeably used for personalized medicine, when actually it is one o...

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Veröffentlicht in:CPT: pharmacometrics and systems pharmacology 2014-04, Vol.3 (4), p.1-11
Hauptverfasser: Jayachandran, D, Ramkrishna, U, Skiles, J, Renbarger, J, Ramkrishna, D
Format: Artikel
Sprache:eng
Schlagworte:
Cancer therapies
Clinical trials
Deoxyribonucleic acid
Disease
DNA
Drug dosages
Gene expression
Genetic disorders
Genomes
Intervention
Metabolism
Patients
Pharmaceutical industry
Precision medicine
Proteins
Review
Signal transduction
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Zusammenfassung:Despite recent advancements in “omic” technologies, personalized medicine has not realized its fullest potential due to isolated and incomplete application of gene expression tools. In many instances, pharmacogenomics is being interchangeably used for personalized medicine, when actually it is one of the many facets of personalized medicine. Herein, we highlight key issues that are hampering the advancement of personalized medicine and highlight emerging predictive tools that can serve as a decision support mechanism for physicians to personalize treatments. CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e110; doi:10.1038/psp.2014.6; published online 16 April 2014
ISSN:2163-8306
2163-8306
DOI:10.1038/psp.2014.6