Isolated and severe left main coronary stenosis in the young: a rare angiographic entity

Extrinsic compression by tumour, aneurysm and patent ductus arteriosus, trauma, spasm and prior surgery are other rare causes. 1 3 Learning points Significant left main (LM) disease is an expression of the most severe form of coronary artery disease (CAD) as it has the potential to compromise blood flow to approximately 75-100% of the left ventricle depending on the coronary dominance thereby placing the patient at high risk for life-threatening events.