Intrahepatic cholestasis in Bruton's agammaglobulinemia receiving mesalamine for co-morbid Crohn's disease

There was onset of abdominal malaise and diarrhea accompanied by hypoalbuminemia, with sharp increase of serum C-reactive protein and fecal calprotectin. Because the family history reported a brother with a confirmed diagnosis of gastro-esophageal Crohn's disease, the patient was referred to us for work-up. [...]rapid normalization of all abnormality contraindicated a liver biopsy. Besides an interesting claim that mesalamines can cause granulomatous hepatitides, [4] we found five reports by matching the terms "mesalazines" with cholestasis in the Medline.