Multivariate prognostic factors analysis for second-line chemotherapy in advanced biliary tract cancer

Background: The role of second-line chemotherapy (CT) is not established in advanced biliary tract cancer (aBTC). We investigated the outcome of aBTC patients treated with second-line CT and devised a prognostic model. Methods: Baseline clinical and laboratory data of 300 consecutive aBTC patients w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2014-04, Vol.110 (9), p.2165-2169
Hauptverfasser:	Fornaro, L, Cereda, S, Aprile, G, Di Girolamo, S, Santini, D, Silvestris, N, Lonardi, S, Leone, F, Milella, M, Vivaldi, C, Belli, C, Bergamo, F, Lutrino, S E, Filippi, R, Russano, M, Vaccaro, V, Brunetti, A E, Rotella, V, Falcone, A, Barbera, M A, Corbelli, J, Fasola, G, Aglietta, M, Zagonel, V, Reni, M, Vasile, E, Brandi, G
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2422 692/699/67/1059/99 692/699/67/1504/1329 Adult Aged Aged, 80 and over Antigens Biliary Tract Neoplasms - drug therapy Biliary Tract Neoplasms - mortality Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Chemotherapy Clinical medicine Clinical Study Disease Progression Disease-Free Survival Drug Resistance Epidemiology Female Gallbladder Gastroenterology. Liver. Pancreas. Abdomen Humans Italy Laboratories Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical prognosis Medical research Medical sciences Metastasis Middle Aged Molecular Medicine Multivariate Analysis Neoplasm Recurrence, Local - epidemiology Oncology Patients Prognosis Retrospective Studies Surgery Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background: The role of second-line chemotherapy (CT) is not established in advanced biliary tract cancer (aBTC). We investigated the outcome of aBTC patients treated with second-line CT and devised a prognostic model. Methods: Baseline clinical and laboratory data of 300 consecutive aBTC patients were collected and association with overall survival (OS) was investigated by multivariable Cox models. Results: The following parameters resulted independently associated with longer OS: Eastern Cooperative Oncology Group performance status of 0 ( P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2014.190