Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches

Highlights • E. coli cyclic-AMP receptor protein (CRP) is a paradigm of gene regulation. • Comparison of CRPs reveals differences in their affinity of cAMP. • A range of dependency on cAMP for DNA-binding exists. • CRPs have adapted to function in the specific niches occupied by the bacteria....

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Veröffentlicht in:	Current opinion in microbiology 2014-04, Vol.18 (100), p.1-7
Hauptverfasser:	Green, Jeffrey, Stapleton, Melanie R, Smith, Laura J, Artymiuk, Peter J, Kahramanoglou, Christina, Hunt, Debbie M, Buxton, Roger S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclic AMP - metabolism Cyclic AMP Receptor Protein - metabolism Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli - physiology Gene Expression Regulation, Bacterial Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Mycobacterium tuberculosis - physiology Pathology Pseudomonas putida Pseudomonas putida - genetics Pseudomonas putida - metabolism Pseudomonas putida - physiology Stress, Physiological
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Zusammenfassung:	Highlights • E. coli cyclic-AMP receptor protein (CRP) is a paradigm of gene regulation. • Comparison of CRPs reveals differences in their affinity of cAMP. • A range of dependency on cAMP for DNA-binding exists. • CRPs have adapted to function in the specific niches occupied by the bacteria.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2014.01.003