Structural biology of the IL‐1 superfamily: Key cytokines in the regulation of immune and inflammatory responses

Interleukin‐1 superfamily of cytokines (IL‐1, IL‐18, IL‐33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL‐1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provid...

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Veröffentlicht in:	Protein science 2014-05, Vol.23 (5), p.526-538
Hauptverfasser:	Krumm, Brian, Xiang, Yan, Deng, Junpeng
Format:	Artikel
Sprache:	eng
Schlagworte:	agonist Animals antagonist Crystallography, X-Ray cytokine Cytokines Humans inflammation Inflammation - drug therapy Inflammation - immunology Intercellular Signaling Peptides and Proteins - chemistry Intercellular Signaling Peptides and Proteins - immunology interleukin Interleukin 1 Receptor Antagonist Protein - chemistry Interleukin 1 Receptor Antagonist Protein - immunology Interleukin-1 - antagonists & inhibitors Interleukin-1 - chemistry Interleukin-1 - immunology Interleukin-18 - chemistry Interleukin-18 - immunology Medical research Models, Molecular Protein Conformation receptors Reviews Signal Transduction
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Beschreibung
Zusammenfassung:	Interleukin‐1 superfamily of cytokines (IL‐1, IL‐18, IL‐33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL‐1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL‐1β and its receptors. We will review here the structural biology related to receptor recognition by IL‐1 superfamily cytokines and the regulation of its cytokine activities by antagonists.
ISSN:	0961-8368 1469-896X
DOI:	10.1002/pro.2441