Covalent protein binding and tissue distribution of houttuynin in rats after intravenous administration of sodium houttuyfonate

Aim： To investigate the potential of houttuynin to covalently bind to proteins in vitro and in vivo and to identify the adduct structures. Methods： Male Sprague-Dawley rats were intravenously injected with sodium houttuyfonate （10 mg/kg）. The concentrations of hout- tuynin in blood, plasma and five...

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Veröffentlicht in:	Acta pharmacologica Sinica 2012-04, Vol.33 (4), p.568-576
Hauptverfasser:	Deng, Zhi-peng, Zhong, Da-fang, Meng, Jian, Chen, Xiao-yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes - administration & dosage Alkanes - chemistry Alkanes - metabolism Alkanes - pharmacokinetics Animals Biomedical and Life Sciences Biomedicine Immunology Injections, Intravenous Internal Medicine Male Medical Microbiology Original original-article Pharmacology/Toxicology Protein Binding Proteins - metabolism Rats Rats, Sprague-Dawley SD大鼠 Sulfites - administration & dosage Sulfites - chemistry Sulfites - metabolism Sulfites - pharmacokinetics Tissue Distribution Vaccine 人血清白蛋白共价组织分布色谱/质谱分析蛋白质静脉注射鱼腥草素钠
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