Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

STIM1 and STIM2 are widely expressed endoplasmic reticulum (ER) Ca 2+ sensor proteins able to translocate within the ER membrane to physically couple with and gate plasma membrane Orai Ca 2+ channels. Although they are structurally similar, we reveal critical differences in the function of the short...

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Veröffentlicht in:	Nature communications 2014-02, Vol.5 (1), p.3183-3183, Article 3183
Hauptverfasser:	Wang, Xizhuo, Wang, Youjun, Zhou, Yandong, Hendron, Eunan, Mancarella, Salvatore, Andrake, Mark D, Rothberg, Brad S, Soboloff, Jonathan, Gill, Donald L
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/95 14/33 14/35 14/63 631/337 631/57/2270 631/80/86/1999 9/74 96/106 96/34 Amino Acid Sequence Binding Sites Calcium Channels - metabolism Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Humanities and Social Sciences Humans Membrane Proteins - chemistry Membrane Proteins - metabolism Molecular Sequence Data multidisciplinary Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism ORAI1 Protein Science Science (multidisciplinary) Sequence Homology, Amino Acid Stromal Interaction Molecule 1 Stromal Interaction Molecule 2
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