Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination

Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tubercul...

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Veröffentlicht in:	Clinical and vaccine immunology 2014-04, Vol.21 (4), p.594-597
Hauptverfasser:	Aguilo, Nacho, Toledo, Ana Maria, Lopez-Roman, Eva Maria, Perez-Herran, Esther, Gormley, Eamonn, Rullas-Trincado, Joaquin, Angulo-Barturen, Iñigo, Martin, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals BCG Vaccine - administration & dosage BCG Vaccine - immunology Colony Count, Microbial Disease Models, Animal Injections, Subcutaneous Lung - immunology Lung - microbiology Mice, Inbred C57BL Mycobacterium bovis Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Spleen - immunology Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - prevention & control Vaccination - methods Vaccines
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Beschreibung
Zusammenfassung:	Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination.
ISSN:	1556-6811 1556-679X 1556-679X
DOI:	10.1128/CVI.00700-13