High-sensitivity Analytical Approaches for the Structural Characterization of Glycoproteins

High-sensitivity bioanalytical methods were used to detail the structural characterization of glycoproteins. Recombinant antibody glycans can be analyzed through high-performance liquid chromatography, capillary electrophoresis with laser-induced fluorescence and capillary electrophoresis-mass spect...

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Veröffentlicht in:	Chemical reviews 2013-04, Vol.113 (4), p.2668-2732
Hauptverfasser:	Alley, William R, Mann, Benjamin F, Novotny, Milos V
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Capillarity Chromatography Chromatography, Liquid Computational Biology Electrophoresis, Capillary Fluorescence Glycomics Glycopeptides - chemistry Glycopeptides - metabolism Glycoprotein Glycoproteins Glycoproteins - analysis Glycoproteins - isolation & purification Glycoproteins - metabolism Glycosylation Mass Spectrometry Mathematical analysis Polysaccharides - chemistry Polysaccharides - isolation & purification Recombinant Sialic Acids - chemistry Spectrometry Structural analysis
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