High-sensitivity Analytical Approaches for the Structural Characterization of Glycoproteins

High-sensitivity Analytical Approaches for the Structural Characterization of Glycoproteins

High-sensitivity bioanalytical methods were used to detail the structural characterization of glycoproteins. Recombinant antibody glycans can be analyzed through high-performance liquid chromatography, capillary electrophoresis with laser-induced fluorescence and capillary electrophoresis-mass spect...

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Veröffentlicht in:Chemical reviews 2013-04, Vol.113 (4), p.2668-2732
Hauptverfasser: Alley, William R, Mann, Benjamin F, Novotny, Milos V
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Capillarity
Chromatography
Chromatography, Liquid
Computational Biology
Electrophoresis, Capillary
Fluorescence
Glycomics
Glycopeptides - chemistry
Glycopeptides - metabolism
Glycoprotein
Glycoproteins
Glycoproteins - analysis
Glycoproteins - isolation & purification
Glycoproteins - metabolism
Glycosylation
Mass Spectrometry
Mathematical analysis
Polysaccharides - chemistry
Polysaccharides - isolation & purification
Recombinant
Sialic Acids - chemistry
Spectrometry
Structural analysis
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Beschreibung
Zusammenfassung:High-sensitivity bioanalytical methods were used to detail the structural characterization of glycoproteins. Recombinant antibody glycans can be analyzed through high-performance liquid chromatography, capillary electrophoresis with laser-induced fluorescence and capillary electrophoresis-mass spectrometry.
ISSN:0009-2665
1520-6890
1520-6890
DOI:10.1021/cr3003714