The dendritic hypothesis for Alzheimer's disease pathophysiology

Highlights • Dendritic neuropathology is ubiquitous in Alzheimer's Disease (AD). • Aβ causes dendritic neuropathology in AD. • Dendritic mislocalization of Tau is an early feature of AD. • Tau mediates dendritic dysfunction in AD models. • Addressing dysfunctional dendritic pathways holds promi...

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Veröffentlicht in:	Brain research bulletin 2014-04, Vol.103, p.18-28
Hauptverfasser:	Cochran, J. Nicholas, Hall, Alicia M, Roberson, Erik D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer Disease - physiopathology Amyloid Amyloid beta-Peptides - metabolism Animals Calcium Dendrites - physiology Dendrites - ultrastructure Fyn Humans Neurites - ultrastructure Neurology Postsynaptic Spine Tau Tauopathies - pathology
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Beschreibung
Zusammenfassung:	Highlights • Dendritic neuropathology is ubiquitous in Alzheimer's Disease (AD). • Aβ causes dendritic neuropathology in AD. • Dendritic mislocalization of Tau is an early feature of AD. • Tau mediates dendritic dysfunction in AD models. • Addressing dysfunctional dendritic pathways holds promise for AD treatment.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2013.12.004