Reduced Bone and Body Mass in Young Male Rats Exposed to Lead

Reduced Bone and Body Mass in Young Male Rats Exposed to Lead

The aim of this study was to see whether there would be differences in whole blood versus tibia lead concentrations over time in growing rats prenatally. Lead was given in the drinking water at 30 mg/L from the time the dams were pregnant until offspring was 28- or 60-day-old. Concentrations of lead...

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Veröffentlicht in:BioMed research international 2014-01, Vol.2014 (2014), p.1-5
Hauptverfasser: Augusto Tocchini de Figueiredo, Fellipe, Gerlach, Raquel Fernanda, Andreia Mesquita Silva da Veiga, Márcia, Venancio Nakadi, Flavio, Ramos, Junia, Reiko Kawakita, Erika, de Souza Guerra, Carolina, Issa, João Paulo Mardegan
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical research
Body Weight - drug effects
Bones
Drinking water
Female
Growth
Health aspects
Lead
Lead - blood
Lead - toxicity
Lead content
Lead poisoning
Male
Maternal Exposure
Medical research
Medicine, Experimental
Pregnancy
Rats
Rodents
Studies
Tibia - chemistry
Tibia - drug effects
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Zusammenfassung:The aim of this study was to see whether there would be differences in whole blood versus tibia lead concentrations over time in growing rats prenatally. Lead was given in the drinking water at 30 mg/L from the time the dams were pregnant until offspring was 28- or 60-day-old. Concentrations of lead were measured in whole blood and in tibia after 28 (28D) and 60 days (60D) in control (C) and in lead-exposed animals (Pb). Lead measurements were made by GF-AAS. There was no significant difference (P>0.05) in the concentration of whole blood lead between Pb-28D (8.0±1.1 μg/dL) and Pb-60D (7.2±0.89 μg/dL), while both significantly varied (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/571065