Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms

Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms

Abstract We determined the effects of maternal diet-induced obesity on offspring adipose tissue insulin signalling and miRNA expression in the aetiology of insulin resistance in later life. Although body composition and glucose tolerance of 8-week-old male offspring of obese dams were not dysregulat...

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Veröffentlicht in:Molecular metabolism (Germany) 2014-06, Vol.3 (3), p.325-333
Hauptverfasser: Fernandez-Twinn, Denise S, Alfaradhi, Maria Z, Martin-Gronert, Malgorzata S, Duque-Guimaraes, Daniella E, Piekarz, Ana, Ferland-McCollough, David, Bushell, Martin, Ozanne, Susan E
Format: Artikel
Sprache:eng
Schlagworte:
Adipose tissue
Endocrinology & Metabolism
Hyperinsulinemia
IRS1
Maternal obesity
microRNAs
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Zusammenfassung:Abstract We determined the effects of maternal diet-induced obesity on offspring adipose tissue insulin signalling and miRNA expression in the aetiology of insulin resistance in later life. Although body composition and glucose tolerance of 8-week-old male offspring of obese dams were not dysregulated, serum insulin was significantly ( p
ISSN:2212-8778
2212-8778
DOI:10.1016/j.molmet.2014.01.007