A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories
With the exception of some French-speaking islands, data on tuberculosis (TB) in the Caribbean are scarce. In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and de...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-11 |
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| creator | Millet, Julie Baboolal, Shirematee Streit, Elisabeth Akpaka, Patrick E. Rastogi, Nalin |
| description | With the exception of some French-speaking islands, data on tuberculosis (TB) in the Caribbean are scarce. In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns. Of the 480 isolates, 40 (8.3%) isolates showed resistance to at least one anti-TB drug. The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P=0.02), and Guyana (27.5%; P |
| doi_str_mv | 10.1155/2014/718496 |
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In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns. Of the 480 isolates, 40 (8.3%) isolates showed resistance to at least one anti-TB drug. The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P=0.02), and Guyana (27.5%; P<0.0001), while it was significantly lower in Jamaica (2.4%; P=0.03) than in other countries of the present study. Regarding genetic diversity, 104 distinct spoligotype patterns were observed: 49 corresponded to clustered strains (2 to 93 strains per cluster), while 55 remained unclustered among which 16 patterns were not reported previously. Combining the study results with regional data retrieved from the international SITVIT2 database underlined a connection between frequency of certain M. tuberculosis phylogenetic lineages and the language spoken, suggesting historical (colonial) and ongoing links (trade, tourism, and migratory flows) with European countries with which they shared a common past.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/718496</identifier><identifier>PMID: 24795893</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adolescent ; Adult ; Aged ; Agedt ; Antitubercular Agents - pharmacology ; Bacteriology ; Biological diversity ; Caribbean Region - epidemiology ; Cloning ; DNA, Bacterial - analysis ; DNA, Bacterial - genetics ; Drug resistance ; Drug resistance in microorganisms ; Drug Resistance, Bacterial - genetics ; Epidemiology ; Female ; Genetic diversity ; Genetic Variation - genetics ; Humans ; Life Sciences ; Male ; Microbial Sensitivity Tests ; Microbiology and Parasitology ; Middle Aged ; Multiculturalism & pluralism ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - classification ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - genetics ; Patients ; Retrospective Studies ; Studies ; Tuberculosis ; Tuberculosis - epidemiology ; Tuberculosis - microbiology ; Young Adult</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-11</ispartof><rights>Copyright © 2014 Julie Millet et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Julie Millet et al. Julie Millet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2014 Julie Millet et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-1fa75f97aefa19236b165a98dc10468c12046f6d2d11f0a38a7b8f3faf1d54bb3</citedby><cites>FETCH-LOGICAL-c528t-1fa75f97aefa19236b165a98dc10468c12046f6d2d11f0a38a7b8f3faf1d54bb3</cites><orcidid>0000-0001-9873-0279 ; 0000-0002-7199-7747</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985416/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985416/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24795893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://riip.hal.science/pasteur-01011078$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Jagielski, Tomasz</contributor><creatorcontrib>Millet, Julie</creatorcontrib><creatorcontrib>Baboolal, Shirematee</creatorcontrib><creatorcontrib>Streit, Elisabeth</creatorcontrib><creatorcontrib>Akpaka, Patrick E.</creatorcontrib><creatorcontrib>Rastogi, Nalin</creatorcontrib><title>A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>With the exception of some French-speaking islands, data on tuberculosis (TB) in the Caribbean are scarce. In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns. Of the 480 isolates, 40 (8.3%) isolates showed resistance to at least one anti-TB drug. The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P=0.02), and Guyana (27.5%; P<0.0001), while it was significantly lower in Jamaica (2.4%; P=0.03) than in other countries of the present study. Regarding genetic diversity, 104 distinct spoligotype patterns were observed: 49 corresponded to clustered strains (2 to 93 strains per cluster), while 55 remained unclustered among which 16 patterns were not reported previously. 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In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns. Of the 480 isolates, 40 (8.3%) isolates showed resistance to at least one anti-TB drug. The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P=0.02), and Guyana (27.5%; P<0.0001), while it was significantly lower in Jamaica (2.4%; P=0.03) than in other countries of the present study. Regarding genetic diversity, 104 distinct spoligotype patterns were observed: 49 corresponded to clustered strains (2 to 93 strains per cluster), while 55 remained unclustered among which 16 patterns were not reported previously. Combining the study results with regional data retrieved from the international SITVIT2 database underlined a connection between frequency of certain M. tuberculosis phylogenetic lineages and the language spoken, suggesting historical (colonial) and ongoing links (trade, tourism, and migratory flows) with European countries with which they shared a common past.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24795893</pmid><doi>10.1155/2014/718496</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9873-0279</orcidid><orcidid>https://orcid.org/0000-0002-7199-7747</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Agedt Antitubercular Agents - pharmacology Bacteriology Biological diversity Caribbean Region - epidemiology Cloning DNA, Bacterial - analysis DNA, Bacterial - genetics Drug resistance Drug resistance in microorganisms Drug Resistance, Bacterial - genetics Epidemiology Female Genetic diversity Genetic Variation - genetics Humans Life Sciences Male Microbial Sensitivity Tests Microbiology and Parasitology Middle Aged Multiculturalism & pluralism Mycobacterium tuberculosis Mycobacterium tuberculosis - classification Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Patients Retrospective Studies Studies Tuberculosis Tuberculosis - epidemiology Tuberculosis - microbiology Young Adult |
| title | A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories |
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