A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories

With the exception of some French-speaking islands, data on tuberculosis (TB) in the Caribbean are scarce. In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and de...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-11
Hauptverfasser:	Millet, Julie, Baboolal, Shirematee, Streit, Elisabeth, Akpaka, Patrick E., Rastogi, Nalin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Agedt Antitubercular Agents - pharmacology Bacteriology Biological diversity Caribbean Region - epidemiology Cloning DNA, Bacterial - analysis DNA, Bacterial - genetics Drug resistance Drug resistance in microorganisms Drug Resistance, Bacterial - genetics Epidemiology Female Genetic diversity Genetic Variation - genetics Humans Life Sciences Male Microbial Sensitivity Tests Microbiology and Parasitology Middle Aged Multiculturalism & pluralism Mycobacterium tuberculosis Mycobacterium tuberculosis - classification Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Patients Retrospective Studies Studies Tuberculosis Tuberculosis - epidemiology Tuberculosis - microbiology Young Adult
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Zusammenfassung:	With the exception of some French-speaking islands, data on tuberculosis (TB) in the Caribbean are scarce. In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns. Of the 480 isolates, 40 (8.3%) isolates showed resistance to at least one anti-TB drug. The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P=0.02), and Guyana (27.5%; P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2014/718496