HERG1 channel agonists and cardiac arrhythmia

HERG1 channel agonists and cardiac arrhythmia

Highlights • hERG1 potassium channels mediate repolarization of cardiac action potentials. • hERG1 agonists alter channel gating to shorten action potential duration and QT interval. • There are four identical agonist binding sites per hERG1 channel. • hERG1 agonists can either prevent or promote ca...

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Veröffentlicht in:Current opinion in pharmacology 2014-04, Vol.15, p.22-27
1. Verfasser: Sanguinetti, Michael C
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials - drug effects
Action Potentials - physiology
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - metabolism
Ether-A-Go-Go Potassium Channels - agonists
Humans
Internal Medicine
Ion Channel Gating - drug effects
Medical Education
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Zusammenfassung:Highlights • hERG1 potassium channels mediate repolarization of cardiac action potentials. • hERG1 agonists alter channel gating to shorten action potential duration and QT interval. • There are four identical agonist binding sites per hERG1 channel. • hERG1 agonists can either prevent or promote cardiac arrhythmia.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2013.11.006