Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma

Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma

Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we...

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Veröffentlicht in:BioMed research international 2014-01, Vol.2014 (2014), p.1-8
Hauptverfasser: Li, Guangbing, Zhang, Haohai, Wan, Xueshuai, Yang, Xiaobo, Zhu, Chengpei, Wang, Anqiang, He, Lian, Miao, Ruoyu, Chen, Shuguang, Zhao, Haitao
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antisense RNA
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell cycle
Cell growth
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Gene expression
Genetic aspects
Genetic disorders
Genomes
Health aspects
Hepatoma
Humans
Liver cancer
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Medical prognosis
Metastasis
Neoplasm Metastasis
Physiological aspects
Prognosis
Proteins
Review
RNA polymerase
RNA, Long Noncoding - metabolism
RNA, Neoplasm - metabolism
Studies
Surgery
Tumors
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Zusammenfassung:Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we give a systematic and comprehensive review of existing literature about lncRNA involvement in hepatocellular carcinoma. This review exhibited that lncRNAs played important roles in tumorigenesis and subsequent prognosis and metastasis of hepatocellular carcinoma and elucidated the role of some specific lncRNAs such as MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma and their potential of being therapeutic targets.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/780521