Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells
The miR-15/107 family comprises a group of 10 paralogous microRNAs （miRNAs）,sharing a 5＇ AGCAGC sequence.These miRNAs have overlapping targets.In order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expres...
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| creator | Wang, Wang-Xia Danaher, Robert J. Miller, Craig S. Berger, Joseph R. Nubia, Vega G. Wilfred, Bernard S. Neltner, Janna H. Norris, Christopher M. Nelson, Peter T. |
| description | The miR-15/107 family comprises a group of 10 paralogous microRNAs （miRNAs）,sharing a 5＇ AGCAGC sequence.These miRNAs have overlapping targets.In order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal muscle.miR-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain samples.We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations （enriched for cortical neurons,astrocytes and microglia,respectively）.In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system （CNS）.In addition to mature miRNAs,we also examined the expression of precursors （pri-miRNAs）.Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors.In summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes. |
| doi_str_mv | 10.1016/j.gpb.2013.10.003 |
| format | Article |
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Production and hosting by Elsevier Ltd.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2014 Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. Production and hosting by Elsevier B.V. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5003-de34c92ab741401043c73b540c58fca4ac0fbbec6c96616b2b4e396831f0f82f3</citedby><cites>FETCH-LOGICAL-c5003-de34c92ab741401043c73b540c58fca4ac0fbbec6c96616b2b4e396831f0f82f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86775X/86775X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975925/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1672022914000035$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,3537,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24480177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Wang-Xia</creatorcontrib><creatorcontrib>Danaher, Robert J.</creatorcontrib><creatorcontrib>Miller, Craig S.</creatorcontrib><creatorcontrib>Berger, Joseph R.</creatorcontrib><creatorcontrib>Nubia, Vega G.</creatorcontrib><creatorcontrib>Wilfred, Bernard S.</creatorcontrib><creatorcontrib>Neltner, Janna H.</creatorcontrib><creatorcontrib>Norris, Christopher M.</creatorcontrib><creatorcontrib>Nelson, Peter T.</creatorcontrib><title>Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells</title><title>Genomics, proteomics & bioinformatics</title><addtitle>Genomics Proteomics ＆ Bioinformatics</addtitle><description>The miR-15/107 family comprises a group of 10 paralogous microRNAs （miRNAs）,sharing a 5＇ AGCAGC sequence.These miRNAs have overlapping targets.In order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal muscle.miR-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain samples.We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations （enriched for cortical neurons,astrocytes and microglia,respectively）.In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system （CNS）.In addition to mature miRNAs,we also examined the expression of precursors （pri-miRNAs）.Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors.In summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.</description><subject>Animals</subject><subject>astrocytes</subject><subject>Brain - metabolism</subject><subject>Cells, Cultured</subject><subject>Cluster Analysis</subject><subject>frontal lobe</subject><subject>Gene Expression Profiling</subject><subject>genes</subject><subject>heart</subject><subject>Humans</subject><subject>kidneys</subject><subject>liver</subject><subject>Microglia - metabolism</subject><subject>microRNA</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miR-15</subject><subject>miR-16</subject><subject>miR-424</subject><subject>miR-503</subject><subject>miRNA</subject><subject>necropsy</subject><subject>neurons</subject><subject>Neurons - metabolism</subject><subject>Normalization</subject><subject>Original Research</subject><subject>phylogeny</subject><subject>Rats</subject><subject>skeletal muscle</subject><subject>spleen</subject><subject>stomach</subject><subject>Target prediction</subject><subject>thalamus</subject><subject>visual cortex</subject><subject>人体组织</subject><subject>培养物</subject><subject>大鼠</subject><subject>家庭</subject><subject>小分子RNA</subject><subject>皮质神经元</subject><subject>脑细胞</subject><issn>1672-0229</issn><issn>2210-3244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1vEzEQtRAVDYUfwAWZG5dNx1_7ISSkNmpppQJSVMTR8nq9qVe7dmpn2yS_HkdJC1zgZI3nzZs37yH0jsCUAMlPu-liWU8pEJbqKQB7gSaUEsgY5fwlmpC8oBlQWh2j1zF2AFxwTl6h49QugRTFBP28WC-DidF6h32LBzvPiDglUOBLNdh-g79aHfz821nE1uGrcVAO39oYRxOxcg2ejf1qDKbBc7XC50El0Mz0fXyDjlrVR_P28J6gH5cXt7Or7Ob7l-vZ2U2mRdKbNYZxXVFVF5xwIMCZLlgtOGhRtlpxpaGta6NzXeU5yWtac8OqvGSkhbakLTtBn_e8y7EeTKONWwXVy2Wwgwob6ZWVf3ecvZML_yBZVYiKikRA9gSPyrXKLWTnx-CSZNlttk293W7i43q9rqVJPu8kAkszHw9Lg79PTqzkYKNOZytn_BglBQBS8VL8H0pEComTsoDfSpLhMQbTPl9BQO7ylp1Mectd3ruvvZL3f57_PPEUcAJ82gNMCuHBmiCjtsZp09hg9Eo23v6T_sNB0p13i3ub7HnawMtKCJ42_AI0ncUK</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Wang, Wang-Xia</creator><creator>Danaher, Robert J.</creator><creator>Miller, Craig S.</creator><creator>Berger, Joseph R.</creator><creator>Nubia, Vega G.</creator><creator>Wilfred, Bernard S.</creator><creator>Neltner, Janna H.</creator><creator>Norris, Christopher M.</creator><creator>Nelson, Peter T.</creator><general>Elsevier Ltd</general><general>Department of Pathology, University of Kentucky, Lexington, KY 40536, USA</general><general>Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA%College of Dentistry, University of Kentucky, Lexington, KY 40536, USA%Department of Neurology, University of Kentucky, Lexington, KY 40536, USA%Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA</general><general>Elsevier</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7S9</scope><scope>L.6</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>201402</creationdate><title>Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells</title><author>Wang, Wang-Xia ; Danaher, Robert J. ; Miller, Craig S. ; Berger, Joseph R. ; Nubia, Vega G. ; Wilfred, Bernard S. ; Neltner, Janna H. ; Norris, Christopher M. ; Nelson, Peter T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5003-de34c92ab741401043c73b540c58fca4ac0fbbec6c96616b2b4e396831f0f82f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>astrocytes</topic><topic>Brain - metabolism</topic><topic>Cells, Cultured</topic><topic>Cluster Analysis</topic><topic>frontal lobe</topic><topic>Gene Expression Profiling</topic><topic>genes</topic><topic>heart</topic><topic>Humans</topic><topic>kidneys</topic><topic>liver</topic><topic>Microglia - metabolism</topic><topic>microRNA</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miR-15</topic><topic>miR-16</topic><topic>miR-424</topic><topic>miR-503</topic><topic>miRNA</topic><topic>necropsy</topic><topic>neurons</topic><topic>Neurons - metabolism</topic><topic>Normalization</topic><topic>Original Research</topic><topic>phylogeny</topic><topic>Rats</topic><topic>skeletal muscle</topic><topic>spleen</topic><topic>stomach</topic><topic>Target prediction</topic><topic>thalamus</topic><topic>visual cortex</topic><topic>人体组织</topic><topic>培养物</topic><topic>大鼠</topic><topic>家庭</topic><topic>小分子RNA</topic><topic>皮质神经元</topic><topic>脑细胞</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Wang-Xia</creatorcontrib><creatorcontrib>Danaher, Robert J.</creatorcontrib><creatorcontrib>Miller, Craig S.</creatorcontrib><creatorcontrib>Berger, Joseph R.</creatorcontrib><creatorcontrib>Nubia, Vega G.</creatorcontrib><creatorcontrib>Wilfred, Bernard S.</creatorcontrib><creatorcontrib>Neltner, Janna H.</creatorcontrib><creatorcontrib>Norris, Christopher M.</creatorcontrib><creatorcontrib>Nelson, Peter T.</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genomics, proteomics & bioinformatics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Wang-Xia</au><au>Danaher, Robert J.</au><au>Miller, Craig S.</au><au>Berger, Joseph R.</au><au>Nubia, Vega G.</au><au>Wilfred, Bernard S.</au><au>Neltner, Janna H.</au><au>Norris, Christopher M.</au><au>Nelson, Peter T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells</atitle><jtitle>Genomics, proteomics & bioinformatics</jtitle><addtitle>Genomics Proteomics ＆ Bioinformatics</addtitle><date>2014-02</date><risdate>2014</risdate><volume>12</volume><issue>1</issue><spage>19</spage><epage>30</epage><pages>19-30</pages><issn>1672-0229</issn><eissn>2210-3244</eissn><abstract>The miR-15/107 family comprises a group of 10 paralogous microRNAs （miRNAs）,sharing a 5＇ AGCAGC sequence.These miRNAs have overlapping targets.In order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal muscle.miR-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain samples.We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations （enriched for cortical neurons,astrocytes and microglia,respectively）.In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system （CNS）.In addition to mature miRNAs,we also examined the expression of precursors （pri-miRNAs）.Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors.In summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.</abstract><cop>China</cop><pub>Elsevier Ltd</pub><pmid>24480177</pmid><doi>10.1016/j.gpb.2013.10.003</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Open Access Collection; MEDLINE; DOAJ Directory of Open Access Journals; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals astrocytes Brain - metabolism Cells, Cultured Cluster Analysis frontal lobe Gene Expression Profiling genes heart Humans kidneys liver Microglia - metabolism microRNA MicroRNAs - genetics MicroRNAs - metabolism miR-15 miR-16 miR-424 miR-503 miRNA necropsy neurons Neurons - metabolism Normalization Original Research phylogeny Rats skeletal muscle spleen stomach Target prediction thalamus visual cortex 人体组织 培养物 大鼠 家庭 小分子RNA 皮质神经元 脑细胞 |
| title | Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells |
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