The Genetics of Pain and Pain Inhibition

The present review summarizes the current state of knowledge about the genetics of pain-related phenomena and illustrates the scope and power of genetic approaches to the study of pain. We focus on work performed in our laboratories in Jastrzebiec, Poland; Portland, OR; and Los Angeles, which we fee...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-04, Vol.93 (7), p.3048-3055
Hauptverfasser:	Mogil, Jeffrey S., Sternberg, Wendy F., Marek, Przemyslaw, Sadowski, Bogdan, Belknap, John K., Liebeskind, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics Animals Crosses, Genetic Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System - genetics Evolutionary genetics Genetics Human genetics Humans Los Angeles Medical genetics Mice Mice, Inbred Strains Mixed Function Oxygenases - genetics Models, Genetic Morphine Neurology Opiates Pain Pain - genetics Pain - physiopathology Pain - prevention & control Perception Phenotypic traits Point Mutation Poland Recombination, Genetic
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Beschreibung
Zusammenfassung:	The present review summarizes the current state of knowledge about the genetics of pain-related phenomena and illustrates the scope and power of genetic approaches to the study of pain. We focus on work performed in our laboratories in Jastrzebiec, Poland; Portland, OR; and Los Angeles, which we feel demonstrates the continuing usefulness of classical genetic approaches, especially when used in combination with newly available molecular genetic techniques.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.93.7.3048